Day hospital versus intensive out-patient mentalisation-based treatment for borderline personality disorder: multicentre randomised clinical trial.
Identifieur interne : 000253 ( Main/Exploration ); précédent : 000252; suivant : 000254Day hospital versus intensive out-patient mentalisation-based treatment for borderline personality disorder: multicentre randomised clinical trial.
Auteurs : Maaike L. Smits [Pays-Bas] ; Dine J. Feenstra [Pays-Bas] ; Hester V. Eeren [Pays-Bas] ; Dawn L. Bales [Pays-Bas] ; Elisabeth M P. Laurenssen [Pays-Bas] ; Matthijs Blankers [Pays-Bas] ; Mirjam B J. Soons [Pays-Bas] ; Jack J M. Dekker [Pays-Bas] ; Zwaan Lucas [Pays-Bas] ; Roel Verheul [Pays-Bas] ; Patrick Luyten [Royaume-Uni]Source :
- The British journal of psychiatry : the journal of mental science [ 1472-1465 ] ; 2020.
Abstract
BACKGROUND
Two types of mentalisation-based treatment (MBT) have been developed and empirically evaluated for borderline personality disorder (BPD): day hospital MBT (MBT-DH) and intensive out-patient MBT (MBT-IOP). No trial has yet compared their efficacy.
AIMS
To compare the efficacy of MBT-DH and MBT-IOP 18 months after start of treatment. MBT-DH was hypothesised to be superior to MBT-IOP because of its higher treatment intensity.
METHOD
In a multicentre randomised controlled trial (Nederlands Trial Register: NTR2292) conducted at three sites in the Netherlands, patients with BPD were randomly assigned to MBT-DH (n = 70) or MBT-IOP (n = 44). The primary outcome was symptom severity (Brief Symptom Inventory). Secondary outcome measures included borderline symptomatology, personality functioning, interpersonal functioning, quality of life and self-harm. Patients were assessed every 6 months from baseline to 18 months after start of treatment. Data were analysed using multilevel modelling based on intention-to-treat principles.
RESULTS
Significant improvements were found on all outcome measures, with moderate to very large effect sizes for both groups. MBT-DH was not superior to MBT-IOP on the primary outcome measure, but MBT-DH showed a clear tendency towards superiority on secondary outcomes.
CONCLUSIONS
Although MBT-DH was not superior to MBT-IOP on the primary outcome measure despite its greater treatment intensity, MBT-DH showed a tendency to be more effective on secondary outcomes, particularly in terms of relational functioning. Patients receiving MBT-DH and MBT-IOP, thus, seem to follow different trajectories of change, which may have important implications for clinical decision-making. Longer-term follow-up and cost-effectiveness considerations may ultimately determine the optimal intensity of specialised treatments such as MBT for patients with BPD.
DOI: 10.1192/bjp.2019.9
PubMed: 30791963
Affiliations:
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Smits</name><affiliation wicri:level="1"><nlm:affiliation>Health Care Psychologist and PhD Student, de Viersprong and the Viersprong Institute for Studies on Personality Disorders, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Health Care Psychologist and PhD Student, de Viersprong and the Viersprong Institute for Studies on Personality Disorders</wicri:regionArea><wicri:noRegion>de Viersprong and the Viersprong Institute for Studies on Personality Disorders</wicri:noRegion></affiliation></author><author><name sortKey="Feenstra, Dine J" sort="Feenstra, Dine J" uniqKey="Feenstra D" first="Dine J" last="Feenstra">Dine J. 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Laurenssen</name><affiliation wicri:level="1"><nlm:affiliation>PhD Student, de Viersprong, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>PhD Student, de Viersprong</wicri:regionArea><wicri:noRegion>de Viersprong</wicri:noRegion></affiliation></author><author><name sortKey="Blankers, Matthijs" sort="Blankers, Matthijs" uniqKey="Blankers M" first="Matthijs" last="Blankers">Matthijs Blankers</name><affiliation wicri:level="1"><nlm:affiliation>Senior Researcher, Netherlands Psychoanalytic Institute, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Senior Researcher, Netherlands Psychoanalytic Institute</wicri:regionArea><wicri:noRegion>Netherlands Psychoanalytic Institute</wicri:noRegion></affiliation></author><author><name sortKey="Soons, Mirjam B J" sort="Soons, Mirjam B J" uniqKey="Soons M" first="Mirjam B J" last="Soons">Mirjam B J. Soons</name><affiliation wicri:level="1"><nlm:affiliation>Psychiatrist and Clinical Psychologist, Netherlands Psychoanalytic Institute, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Psychiatrist and Clinical Psychologist, Netherlands Psychoanalytic Institute</wicri:regionArea><wicri:noRegion>Netherlands Psychoanalytic Institute</wicri:noRegion></affiliation></author><author><name sortKey="Dekker, Jack J M" sort="Dekker, Jack J M" uniqKey="Dekker J" first="Jack J M" last="Dekker">Jack J M. Dekker</name><affiliation wicri:level="1"><nlm:affiliation>Professor, Department of Clinical Psychology, dr. Vrije University Amsterdam; and Netherlands Psychoanalytic Institute, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Professor, Department of Clinical Psychology, dr. Vrije University Amsterdam; and Netherlands Psychoanalytic Institute</wicri:regionArea><wicri:noRegion>dr. Vrije University Amsterdam; and Netherlands Psychoanalytic Institute</wicri:noRegion></affiliation></author><author><name sortKey="Lucas, Zwaan" sort="Lucas, Zwaan" uniqKey="Lucas Z" first="Zwaan" last="Lucas">Zwaan Lucas</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Psychologist and Psychotherapist, Lentis, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Clinical Psychologist and Psychotherapist, Lentis</wicri:regionArea><wicri:noRegion>Lentis</wicri:noRegion></affiliation></author><author><name sortKey="Verheul, Roel" sort="Verheul, Roel" uniqKey="Verheul R" first="Roel" last="Verheul">Roel Verheul</name><affiliation wicri:level="1"><nlm:affiliation>de Viersprong, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>de Viersprong</wicri:regionArea></affiliation></author><author><name sortKey="Luyten, Patrick" sort="Luyten, Patrick" uniqKey="Luyten P" first="Patrick" last="Luyten">Patrick Luyten</name><affiliation wicri:level="4"><nlm:affiliation>Professor, Doctor, Faculty of Psychology and Educational Sciences, University of Leuven, Belgium; and Research Department of Clinical, Educational and Health Psychology, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Professor, Doctor, Faculty of Psychology and Educational Sciences, University of Leuven, Belgium; and Research Department of Clinical, Educational and Health Psychology, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:30791963</idno><idno type="pmid">30791963</idno><idno type="doi">10.1192/bjp.2019.9</idno><idno type="wicri:Area/Main/Corpus">000568</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000568</idno><idno type="wicri:Area/Main/Curation">000568</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000568</idno><idno type="wicri:Area/Main/Exploration">000568</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Day hospital versus intensive out-patient mentalisation-based treatment for borderline personality disorder: multicentre randomised clinical trial.</title><author><name sortKey="Smits, Maaike L" sort="Smits, Maaike L" uniqKey="Smits M" first="Maaike L" last="Smits">Maaike L. Smits</name><affiliation wicri:level="1"><nlm:affiliation>Health Care Psychologist and PhD Student, de Viersprong and the Viersprong Institute for Studies on Personality Disorders, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Health Care Psychologist and PhD Student, de Viersprong and the Viersprong Institute for Studies on Personality Disorders</wicri:regionArea><wicri:noRegion>de Viersprong and the Viersprong Institute for Studies on Personality Disorders</wicri:noRegion></affiliation></author><author><name sortKey="Feenstra, Dine J" sort="Feenstra, Dine J" uniqKey="Feenstra D" first="Dine J" last="Feenstra">Dine J. Feenstra</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Psychologist and Principal Investigator, de Viersprong, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Clinical Psychologist and Principal Investigator, de Viersprong</wicri:regionArea><wicri:noRegion>de Viersprong</wicri:noRegion></affiliation></author><author><name sortKey="Eeren, Hester V" sort="Eeren, Hester V" uniqKey="Eeren H" first="Hester V" last="Eeren">Hester V. Eeren</name><affiliation wicri:level="1"><nlm:affiliation>PhD Student, de Viersprong, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>PhD Student, de Viersprong</wicri:regionArea><wicri:noRegion>de Viersprong</wicri:noRegion></affiliation></author><author><name sortKey="Bales, Dawn L" sort="Bales, Dawn L" uniqKey="Bales D" first="Dawn L" last="Bales">Dawn L. Bales</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Psychologist and Director Expertcentre MBT-Netherlands, de Viersprong; and Expertcentre MBT-Netherlands, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Clinical Psychologist and Director Expertcentre MBT-Netherlands, de Viersprong; and Expertcentre MBT-Netherlands</wicri:regionArea><wicri:noRegion>de Viersprong; and Expertcentre MBT-Netherlands</wicri:noRegion></affiliation></author><author><name sortKey="Laurenssen, Elisabeth M P" sort="Laurenssen, Elisabeth M P" uniqKey="Laurenssen E" first="Elisabeth M P" last="Laurenssen">Elisabeth M P. Laurenssen</name><affiliation wicri:level="1"><nlm:affiliation>PhD Student, de Viersprong, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>PhD Student, de Viersprong</wicri:regionArea><wicri:noRegion>de Viersprong</wicri:noRegion></affiliation></author><author><name sortKey="Blankers, Matthijs" sort="Blankers, Matthijs" uniqKey="Blankers M" first="Matthijs" last="Blankers">Matthijs Blankers</name><affiliation wicri:level="1"><nlm:affiliation>Senior Researcher, Netherlands Psychoanalytic Institute, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Senior Researcher, Netherlands Psychoanalytic Institute</wicri:regionArea><wicri:noRegion>Netherlands Psychoanalytic Institute</wicri:noRegion></affiliation></author><author><name sortKey="Soons, Mirjam B J" sort="Soons, Mirjam B J" uniqKey="Soons M" first="Mirjam B J" last="Soons">Mirjam B J. Soons</name><affiliation wicri:level="1"><nlm:affiliation>Psychiatrist and Clinical Psychologist, Netherlands Psychoanalytic Institute, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Psychiatrist and Clinical Psychologist, Netherlands Psychoanalytic Institute</wicri:regionArea><wicri:noRegion>Netherlands Psychoanalytic Institute</wicri:noRegion></affiliation></author><author><name sortKey="Dekker, Jack J M" sort="Dekker, Jack J M" uniqKey="Dekker J" first="Jack J M" last="Dekker">Jack J M. Dekker</name><affiliation wicri:level="1"><nlm:affiliation>Professor, Department of Clinical Psychology, dr. Vrije University Amsterdam; and Netherlands Psychoanalytic Institute, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Professor, Department of Clinical Psychology, dr. Vrije University Amsterdam; and Netherlands Psychoanalytic Institute</wicri:regionArea><wicri:noRegion>dr. Vrije University Amsterdam; and Netherlands Psychoanalytic Institute</wicri:noRegion></affiliation></author><author><name sortKey="Lucas, Zwaan" sort="Lucas, Zwaan" uniqKey="Lucas Z" first="Zwaan" last="Lucas">Zwaan Lucas</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Psychologist and Psychotherapist, Lentis, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Clinical Psychologist and Psychotherapist, Lentis</wicri:regionArea><wicri:noRegion>Lentis</wicri:noRegion></affiliation></author><author><name sortKey="Verheul, Roel" sort="Verheul, Roel" uniqKey="Verheul R" first="Roel" last="Verheul">Roel Verheul</name><affiliation wicri:level="1"><nlm:affiliation>de Viersprong, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>de Viersprong</wicri:regionArea></affiliation></author><author><name sortKey="Luyten, Patrick" sort="Luyten, Patrick" uniqKey="Luyten P" first="Patrick" last="Luyten">Patrick Luyten</name><affiliation wicri:level="4"><nlm:affiliation>Professor, Doctor, Faculty of Psychology and Educational Sciences, University of Leuven, Belgium; and Research Department of Clinical, Educational and Health Psychology, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Professor, Doctor, Faculty of Psychology and Educational Sciences, University of Leuven, Belgium; and Research Department of Clinical, Educational and Health Psychology, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author></analytic><series><title level="j">The British journal of psychiatry : the journal of mental science</title><idno type="eISSN">1472-1465</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Two types of mentalisation-based treatment (MBT) have been developed and empirically evaluated for borderline personality disorder (BPD): day hospital MBT (MBT-DH) and intensive out-patient MBT (MBT-IOP). No trial has yet compared their efficacy.</p></div><div type="abstract" xml:lang="en"><p><b>AIMS</b></p><p>To compare the efficacy of MBT-DH and MBT-IOP 18 months after start of treatment. MBT-DH was hypothesised to be superior to MBT-IOP because of its higher treatment intensity.</p></div><div type="abstract" xml:lang="en"><p><b>METHOD</b></p><p>In a multicentre randomised controlled trial (Nederlands Trial Register: NTR2292) conducted at three sites in the Netherlands, patients with BPD were randomly assigned to MBT-DH (n = 70) or MBT-IOP (n = 44). The primary outcome was symptom severity (Brief Symptom Inventory). Secondary outcome measures included borderline symptomatology, personality functioning, interpersonal functioning, quality of life and self-harm. Patients were assessed every 6 months from baseline to 18 months after start of treatment. Data were analysed using multilevel modelling based on intention-to-treat principles.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Significant improvements were found on all outcome measures, with moderate to very large effect sizes for both groups. MBT-DH was not superior to MBT-IOP on the primary outcome measure, but MBT-DH showed a clear tendency towards superiority on secondary outcomes.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Although MBT-DH was not superior to MBT-IOP on the primary outcome measure despite its greater treatment intensity, MBT-DH showed a tendency to be more effective on secondary outcomes, particularly in terms of relational functioning. Patients receiving MBT-DH and MBT-IOP, thus, seem to follow different trajectories of change, which may have important implications for clinical decision-making. Longer-term follow-up and cost-effectiveness considerations may ultimately determine the optimal intensity of specialised treatments such as MBT for patients with BPD.</p></div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">30791963</PMID><DateRevised><Year>2020</Year><Month>07</Month><Day>27</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1472-1465</ISSN><JournalIssue CitedMedium="Internet"><Volume>216</Volume><Issue>2</Issue><PubDate><Year>2020</Year><Month>02</Month></PubDate></JournalIssue><Title>The British journal of psychiatry : the journal of mental science</Title><ISOAbbreviation>Br J Psychiatry</ISOAbbreviation></Journal><ArticleTitle>Day hospital versus intensive out-patient mentalisation-based treatment for borderline personality disorder: multicentre randomised clinical trial.</ArticleTitle><Pagination><MedlinePgn>79-84</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1192/bjp.2019.9</ELocationID><Abstract><AbstractText Label="BACKGROUND">Two types of mentalisation-based treatment (MBT) have been developed and empirically evaluated for borderline personality disorder (BPD): day hospital MBT (MBT-DH) and intensive out-patient MBT (MBT-IOP). No trial has yet compared their efficacy.</AbstractText><AbstractText Label="AIMS">To compare the efficacy of MBT-DH and MBT-IOP 18 months after start of treatment. MBT-DH was hypothesised to be superior to MBT-IOP because of its higher treatment intensity.</AbstractText><AbstractText Label="METHOD">In a multicentre randomised controlled trial (Nederlands Trial Register: NTR2292) conducted at three sites in the Netherlands, patients with BPD were randomly assigned to MBT-DH (n = 70) or MBT-IOP (n = 44). The primary outcome was symptom severity (Brief Symptom Inventory). Secondary outcome measures included borderline symptomatology, personality functioning, interpersonal functioning, quality of life and self-harm. Patients were assessed every 6 months from baseline to 18 months after start of treatment. Data were analysed using multilevel modelling based on intention-to-treat principles.</AbstractText><AbstractText Label="RESULTS">Significant improvements were found on all outcome measures, with moderate to very large effect sizes for both groups. MBT-DH was not superior to MBT-IOP on the primary outcome measure, but MBT-DH showed a clear tendency towards superiority on secondary outcomes.</AbstractText><AbstractText Label="CONCLUSIONS">Although MBT-DH was not superior to MBT-IOP on the primary outcome measure despite its greater treatment intensity, MBT-DH showed a tendency to be more effective on secondary outcomes, particularly in terms of relational functioning. Patients receiving MBT-DH and MBT-IOP, thus, seem to follow different trajectories of change, which may have important implications for clinical decision-making. Longer-term follow-up and cost-effectiveness considerations may ultimately determine the optimal intensity of specialised treatments such as MBT for patients with BPD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Smits</LastName><ForeName>Maaike L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Health Care Psychologist and PhD Student, de Viersprong and the Viersprong Institute for Studies on Personality Disorders, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feenstra</LastName><ForeName>Dine J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Clinical Psychologist and Principal Investigator, de Viersprong, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eeren</LastName><ForeName>Hester V</ForeName><Initials>HV</Initials><AffiliationInfo><Affiliation>PhD Student, de Viersprong, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bales</LastName><ForeName>Dawn L</ForeName><Initials>DL</Initials><AffiliationInfo><Affiliation>Clinical Psychologist and Director Expertcentre MBT-Netherlands, de Viersprong; and Expertcentre MBT-Netherlands, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laurenssen</LastName><ForeName>Elisabeth M P</ForeName><Initials>EMP</Initials><AffiliationInfo><Affiliation>PhD Student, de Viersprong, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blankers</LastName><ForeName>Matthijs</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Senior Researcher, Netherlands Psychoanalytic Institute, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soons</LastName><ForeName>Mirjam B J</ForeName><Initials>MBJ</Initials><AffiliationInfo><Affiliation>Psychiatrist and Clinical Psychologist, Netherlands Psychoanalytic Institute, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dekker</LastName><ForeName>Jack J M</ForeName><Initials>JJM</Initials><AffiliationInfo><Affiliation>Professor, Department of Clinical Psychology, dr. Vrije University Amsterdam; and Netherlands Psychoanalytic Institute, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lucas</LastName><ForeName>Zwaan</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Clinical Psychologist and Psychotherapist, Lentis, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verheul</LastName><ForeName>Roel</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>de Viersprong, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luyten</LastName><ForeName>Patrick</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Professor, Doctor, Faculty of Psychology and Educational Sciences, University of Leuven, Belgium; and Research Department of Clinical, Educational and Health Psychology, University College London, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Br J Psychiatry</MedlineTA><NlmUniqueID>0342367</NlmUniqueID><ISSNLinking>0007-1250</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Mentalisation-Based Treatment</Keyword><Keyword MajorTopicYN="Y">borderline personality disorder</Keyword><Keyword MajorTopicYN="Y">randomized controlled trial</Keyword><Keyword MajorTopicYN="Y">treatment intensity</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>2</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>2</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>2</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30791963</ArticleId><ArticleId IdType="pii">S0007125019000096</ArticleId><ArticleId IdType="doi">10.1192/bjp.2019.9</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>University College de Londres</li></orgName></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Smits, Maaike L" sort="Smits, Maaike L" uniqKey="Smits M" first="Maaike L" last="Smits">Maaike L. Smits</name></noRegion><name sortKey="Bales, Dawn L" sort="Bales, Dawn L" uniqKey="Bales D" first="Dawn L" last="Bales">Dawn L. Bales</name><name sortKey="Blankers, Matthijs" sort="Blankers, Matthijs" uniqKey="Blankers M" first="Matthijs" last="Blankers">Matthijs Blankers</name><name sortKey="Dekker, Jack J M" sort="Dekker, Jack J M" uniqKey="Dekker J" first="Jack J M" last="Dekker">Jack J M. Dekker</name><name sortKey="Eeren, Hester V" sort="Eeren, Hester V" uniqKey="Eeren H" first="Hester V" last="Eeren">Hester V. Eeren</name><name sortKey="Feenstra, Dine J" sort="Feenstra, Dine J" uniqKey="Feenstra D" first="Dine J" last="Feenstra">Dine J. Feenstra</name><name sortKey="Laurenssen, Elisabeth M P" sort="Laurenssen, Elisabeth M P" uniqKey="Laurenssen E" first="Elisabeth M P" last="Laurenssen">Elisabeth M P. Laurenssen</name><name sortKey="Lucas, Zwaan" sort="Lucas, Zwaan" uniqKey="Lucas Z" first="Zwaan" last="Lucas">Zwaan Lucas</name><name sortKey="Soons, Mirjam B J" sort="Soons, Mirjam B J" uniqKey="Soons M" first="Mirjam B J" last="Soons">Mirjam B J. Soons</name><name sortKey="Verheul, Roel" sort="Verheul, Roel" uniqKey="Verheul R" first="Roel" last="Verheul">Roel Verheul</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Luyten, Patrick" sort="Luyten, Patrick" uniqKey="Luyten P" first="Patrick" last="Luyten">Patrick Luyten</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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